Collaboration goals to seize patient-to-patient variability to find out the very best therapy for each most cancers
SALT LAKE CITY & RALEIGH, N.C., March 03, 2022–(BUSINESS WIRE)–Recognized Drugs, a rising biotechnology powerhouse aimed to find new most cancers medication, introduced a partnership with Duke College to foretell drug efficacy for lung most cancers sufferers. This collaboration will allow Recognized Drugs to optimize and validate their novel ODINTM platform. Duke College collaborator, Kamran Mahmood, MD, MPH, is the lead collaborator on this initiative. Collectively, Recognized Drugs and Duke College purpose to find out if Recognized Drugs’s novel platform can be utilized to foretell precise medical outcomes in 75 sufferers.
“We’re extremely grateful for the chance to companion with Dr. Kamran Mahmood and the better Duke College group. As one of many main most cancers institutes within the nation, this partnership permits us to generate medical, organic, and computational insights to enhance most cancers affected person lives,” stated Andrea Mazzocchi, PhD, CEO and co-founder at Recognized Drugs.
“This collaboration with start-up Recognized Drugs will allow clinicians to offer customized remedy to their sufferers. We’re excited to be a part of the Recognized Drugs group and sit up for future collaborations and tasks to enhance affected person care and therapy for lung most cancers,” stated Mahmood, Affiliate Professor of Drugs at Duke.
Recognized Drugs generates hundreds of third-dimensional (3D) micro-tumors from a single affected person tumor or malignant pleural effusion pattern. Every micro-tumor is then handled with a distinct drug or mixture of medicine. Excessive-content pictures are obtained and analyzed to watch the response to therapy and establish the very best therapy for every most cancers.
Recognized Drugs is ready to take the experiment out of the affected person by testing a whole bunch of medicine in parallel on their micro-tumor platform whereas observing how the patient-specific most cancers cells reply. Their machine learning-based evaluation depends on high-content pictures of those 3D micro-tumors to higher perceive why cells reply to 1 therapy over one other. Practical outcomes are mixed with excessive dimensional -omics datasets to establish the very best sufferers for current medication, and the very best potential new drug candidates.
About Recognized Drugs
Primarily based in Salt Lake Metropolis, Utah, Recognized Drugs is constructing a predictive engine to seize patient-to-patient variability and develop the very best drug for each most cancers. Recognized Drugs merges biomaterials and most cancers biology with machine studying to create a singular dataset comprising practical therapy outcomes and immunologic, genomic, and proteomic profiles for each affected person. By understanding how and why a affected person responds to which remedy, Recognized Drugs is ready to develop efficient drug remedies with a excessive chance of success, and uncover new medication as its engine strengthens. Be taught extra at www.knownmed.com, or join on Twitter and LinkedIn.
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Medical Challenge Supervisor
Kamran Mahmood, MD, MPH
Affiliate Professor of Drugs, Duke College